Purpose
Gene
Testing to Help in the Diagnosis and Treatment of Childhood Brain Tumors
This study
is currently recruiting patients.
Sponsored by
National Cancer Institute
(NCI)
Children's Cancer Group
Purpose
RATIONALE: Analyzing the number and
structure of genes found in a child's cancer cells may help doctors improve methods of
diagnosing and treating children with brain tumors. PURPOSE: Clinical trial to study the
number and structure of genes in cancer cells of children who have brain tumors.
Condition
|
untreated
childhood supratentorial primitive neuroectodermal and pineal tumors untreated childhood medulloblastoma |
Study Type: Genetic
Official Title: Molecular Biology of Pediatric Brain Tumors
Further Study Details: OBJECTIVES: I. Determine the chromosomal
gains and lossed by DNA ploidy analysis and comparative genomic hybridization in patients
with primitive neuroectodermal tumors or medulloblastomas. II. Determine the frequency of
specific chromosomal abnormalities, including deletions of chromosomal regions 6, 17, and
22, in these patients. III. Perform a statistical analysis to determine possible
associations of chromosomal abnormalities and DNA ploidy with patient age, tumor
histology, tumor location, extent of disease, and event-free survival. PROTOCOL
OUTLINE: DNA ploidy analysis will be performed to determine the overall level of
aneuploidy. The results are compared to the comparative genomic hybridization (CGH)
analysis, which is used to demonstrate tumor-specific losses or gains, including
amplification, of specific chromosomal regions. Tumors are also screened for specific
abnormalities by fluorescent in situ hybridization (FISH), which detects chromosomal
rearrangements, including balanced translocations, deletions, amplifications, etc.
PCR-based microsatellite polymorphism analysis may also be performed. Primitive
neuroectodermal tumors (PNETs) are screened by FISH with a distal 17p13.3 cosmid and a
17q25 cosmid to identify tumors with a 17p deletion. Atypical teratoid/rhabdoid tumors and
PNETs without a 17p deletion are screened by FISH with a series of cosmids from 22q11.2.
PNETs are also screened by interphase FISH with cosmids from chromosome 6 to identify
tumors with deletions. Patients do not receive the results of the genetic testing and the
results do not influence the type or duration of treatment. PROJECTED ACCRUAL: This
study will accrue 360 specimens.
Eligibility
Ages Eligible for Study: up to
20 Years Criteria
PROTOCOL ENTRY CRITERIA: --Disease
Characteristics-- Histologically confirmed primary CNS malignancy consistent with
primitive neuroectodermal tumor, medulloblastoma, or atypical teratoid/rhabdoid tumor Must
be entered on CCG-9921, CCG-9931, CCG-A9961, CCG-99703 or other front-line studies
developed from CCG-90024 or CCG-90025 Retrospective specimens also obtained from CCG-921,
CCG-923, CCG-9892, CCG-9921, and CCG-9931 --Prior/Concurrent Therapy-- No prior
radiotherapy --Patient Characteristics-- Age: Under 21 Performance status: See Disease
Characteristics Life expectancy: See Disease Characteristics Hematopoietic: See Disease
Characteristics Hepatic: See Disease Characteristics Renal: See Disease Characteristics
Location and Contact Information
Western Australia, Australia
Princess Margaret Hospital for
Children, Perth, Western Australia, 6001,
Australia; Recruiting
David Baker
011-618-9340-8234
British Columbia, Canada
British Columbia Children's
Hospital, Vancouver, British Columbia, V6H 3V4,
Canada; Recruiting
Paul C.J. Rogers
604-875-2322
Nova Scotia, Canada
IWK Grace Health Centre, Halifax,
Nova Scotia, B3J 3G9, Canada; Recruiting
Dorothy R. Barnard
902-428-8291
California
Children's Hospital Los Angeles, Los
Angeles, California, 90027-0700, United
States; Recruiting
Paul S. Gaynon
323-669-2163
California
Children's Hospital of Orange
County, Orange, California, 92668, United
States; Recruiting
Wei-Ping Violet Shen
714-532-8628
California
Jonsson Comprehensive Cancer Center,
UCLA, Los Angeles, California, 90095-1781, United
States; Recruiting
Stephen A. Feig
310-825-6708
California
Long Beach Memorial Medical
Center, Long Beach, California, 90806, United
States; Recruiting
Jerry Z. Finklestein
310-492-1062
California
UCSF Cancer Center and Cancer Research
Institute, San Francisco, California, 94115-0128,
United States; Recruiting
Katherine K. Matthay
415-476-0603
Colorado
Children's Hospital of Denver, Denver,
Colorado, 80218, United States; Recruiting
Lorrie F. Odom
303-861-6750
District of Columbia
Children's National Medical
Center, Washington, District of Columbia, 20010-2970,
United States; Recruiting
Gregory H. Reaman
202-884-2147
Illinois
University of Chicago Cancer Research
Center, Chicago, Illinois, 60637, United
States; Recruiting
James B. Nachman
773-702-6808
Indiana
Indiana University Cancer
Center, Indianapolis, Indiana, 46202-5265, United
States; Recruiting
Philip Paul Breitfeld
317-274-8982
Iowa
University of Iowa Hospitals and
Clinics, Iowa City, Iowa, 52242, United
States; Recruiting
Raymond Tannous
319-356-1905
Michigan
CCOP - Kalamazoo, Kalamazoo,
Michigan, 49007-3731, United States; Recruiting
Raymond S. Lord, III
616-373-7488
Michigan
University of Michigan Comprehensive Cancer
Center, Ann Arbor, Michigan, 48109-0752, United
States; Recruiting
Raymond J. Hutchinson
313-936-8785
Minnesota
Mayo Clinic Cancer Center, Rochester,
Minnesota, 55905, United States; Recruiting
Carola A.S. Arndt
507-284-3903
Minnesota
University of Minnesota Cancer
Center, Minneapolis, Minnesota, 55455, United
States; Recruiting
Joseph P. Neglia
612-626-2778
Missouri
Children's Mercy Hospital - Kansas
City, Kansas City, Missouri, 64108, United
States; Recruiting
Maxine L. Hetherington
816-234-3265
Nebraska
University of Nebraska Medical
Center, Omaha, Nebraska, 68198-3330, United
States; Recruiting
Peter F. Coccia
402-559-7257
New Jersey
Cancer Institute of New Jersey, New
Brunswick, New Jersey, 08901, United
States; Recruiting
Richard A. Drachtman
732-235-7898
New York
Herbert Irving Comprehensive Cancer
Center, New York, New York, 10032, United
States; Recruiting
Michael A. Weiner
212-305-5808
New York
Kaplan Cancer Center, New York,
New York, 10016, United States; Recruiting
Aaron R. Rausen
212-263-7144
New York
Memorial Sloan-Kettering Cancer
Center, New York, New York, 10021, United
States; Recruiting
Peter G. Steinherz
212-639-7951
North Carolina
Lineberger Comprehensive Cancer Center,
UNC, Chapel Hill, North Carolina, 27599-7295,
United States; Recruiting
Stuart Gold
919-966-1178
North Dakota
CCOP - Merit Care Hospital, Fargo,
North Dakota, 58122, United States; Recruiting
Ralph Levitt
701-234-7592
North Dakota
Veterans Affairs Medical Center -
Fargo, Fargo, North Dakota, 58102, United
States; Recruiting
Ralph Levitt
701-234-7592
Ohio
Children's Hospital Medical Center -
Cincinnati, Cincinnati, Ohio, 45229-3039, United
States; Recruiting
Robert J. Wells
513-636-4266
Ohio
Children's Hospital of
Columbus, Columbus, Ohio, 43205-2696, United
States; Recruiting
Frederick B. Ruymann
614-722-3564
Ohio
Ireland Cancer Center, Cleveland,
Ohio, 44106-5065, United States; Recruiting
Eric Kodish
216-844-3345
Oregon
Doernbecher Children's
Hospital, Portland, Oregon, 97201-3098, United
States; Recruiting
H. Stacy Nicholson
503-494-1543
Pennsylvania
Children's Hospital of
Philadelphia, Philadelphia, Pennsylvania, 19104,
United States; Recruiting
Beverly J. Lange
215-590-2249
Pennsylvania
Children's Hospital of
Pittsburgh, Pittsburgh, Pennsylvania, 15213,
United States; Recruiting
Arthur Kim Ritchey
412-692-5949
Tennessee
Vanderbilt Cancer Center, Nashville,
Tennessee, 37232-6838, United States; Recruiting
James A. Whitlock
615-936-1762
Texas
University of Texas - MD Anderson Cancer
Center, Houston, Texas, 77030, United
States; Recruiting
R. Beverly Raney, Jr.
713-792-6624
Utah
Huntsman Cancer Institute, Salt Lake
City, Utah, 84132, United States; Recruiting
William L. Carroll
801-588-2680
Washington
Children's Hospital and Regional Medical
Center - Seattle, Seattle, Washington, 98105,
United States; Recruiting
J. Russell Geyer
206-526-2106
Washington
Fred Hutchinson Cancer Research
Center, Seattle, Washington, 98109, United
States; Recruiting
Jean E. Sanders
206-667-4348
Wisconsin
University of Wisconsin Comprehensive
Cancer Center, Madison, Wisconsin, 53792, United
States; Recruiting
Diane Puccetti
608-263-0320
Study chairs or principal investigators
Jaclyn A. Biegel, Study Chair
Children's Cancer Group
More Information
Study ID Numbers 199/12889;
CCG-B971
NLM Identifier NCT00003096
Date study started December 1, 1997